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KMID : 0858619990030010063
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Korean Journal of Audiology
1999 Volume.3 No. 1 p.63 ~ p.70
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A Study for Brainstem c-Fos Protein Expression during Bechterew Compensation in Rats
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이재훈/Jae Hoon Lee
Min Sun Kim/Oh Sung Hwang
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Abstract
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The present study was aimed to investigate the temporospatial changes of c-Fos protein expression in medial vestibular nucleus (MVN), inferior vstibular nucleus (IVN), prepositus hypoglossal nucleus (PRH), and inferior olivary nucleus (ION) during Bechterew compensation, a gradual disappearance of vestibular dysfunctions after second labyrinthectomy (LX) in subjects receiving unilateral LX previously. Sprague-Dawley rats were given the second right LX 50-60 days after the first left labyrinthectomy to induce Bechterew compensation. Beat number of spontaneous nystagmus was 23.7±3.2/10sec 4 hrs after the second LX, which was decreased progressively in the course of Bechterew compensation and disappeared 48 hrs after the second LX. c-Fos (＋) neurons were observed in the bilateral MVN 2 hrs after the second LX. However c-Fos expression was not symmetrical, which showed continuous induction in ipsilateral MVN (iMVN), whereas less expression in contralateral MVN (cMVN). Significant increase of c-Fos neurons was observed in cIVN but not in iIVN c-Fos expression in PRH and ION was the same pattern as in ULX spatially and temporally. These results suggest that temporal change of c-Fos expression in the brain stem represent generation of new synaptic plasticity during Bechterew compensation in rats.
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